| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | Bucks | 132 | Pacers | 122 |
| November | 4, 2021 | 76ers | 117 | Bucks | 136 |
| November | 5, 2021 | Sonics | 118 | Bucks | 127 |
| November | 8, 2021 | Nets | 114 | Bucks | 134 |
| November | 9, 2021 | Bucks | 123 | Pacers | 122 |
| November | 11, 2021 | Mavericks | 122 | Bucks | 114 |
| November | 12, 2021 | Pacers | 97 | Bucks | 130 |
| November | 16, 2021 | Bulls | 104 | Bucks | 122 |
| November | 18, 2021 | Bucks | 120 | 76ers | 114 |
| November | 19, 2021 | Knicks | 131 | Bucks | 124 |
| November | 20, 2021 | Lakers | 106 | Bucks | 128 |
| November | 23, 2021 | Hawks | 114 | Bucks | 119 |
| November | 26, 2021 | Bucks | 122 | Bulls | 118 |
| November | 29, 2021 | Bucks | 112 | Celtics | 154 |
| November | 30, 2021 | Bucks | 118 | Hawks | 129 |
| December | 4, 2021 | Bucks | 117 | Blazers | 123 |
| December | 6, 2021 | Bucks | 146 | Pelicans | 157 |
| December | 7, 2021 | Bucks | 95 | Spurs | 114 |
| December | 8, 2021 | Bucks | 118 | Sonics | 127 |
| December | 15, 2021 | Knicks | 131 | Bucks | 105 |
| December | 16, 2021 | Bucks | 102 | Suns | 121 |
| December | 17, 2021 | 76ers | 99 | Bucks | 119 |
| December | 18, 2021 | Bucks | 132 | Pacers | 119 |
| December | 19, 2021 | Bucks | 105 | Wolves | 106 |
| December | 22, 2021 | Bucks | 97 | Raptors | 147 |
| December | 23, 2021 | Grizzlies | 127 | Bucks | 110 |
| December | 25, 2021 | Bucks | 99 | Hawks | 128 |
| December | 27, 2021 | Raptors | 146 | Bucks | 134 |
| December | 28, 2021 | Bucks | 108 | Nets | 105 |
| January | 1, 2022 | Pelicans | 119 | Bucks | 123 |
| January | 3, 2022 | Heat | 114 | Bucks | 130 |
| January | 4, 2022 | Bucks | 116 | Mavericks | 117 |
| January | 5, 2022 | Knicks | 109 | Bucks | 126 |
| January | 8, 2022 | Bucks | 115 | Kings | 124 |
| January | 11, 2022 | Blazers | 112 | Bucks | 122 |
| January | 12, 2022 | Raptors | 111 | Bucks | 126 |
| January | 13, 2022 | Bucks | 124 | Knicks | 123 |
| January | 14, 2022 | Bucks | 118 | 76ers | 128 |
| January | 18, 2022 | Bucks | 122 | Pacers | 113 |
| January | 21, 2022 | Bucks | 126 | Heat | 135 |
| January | 23, 2022 | Bucks | 99 | Hawks | 130 |
| January | 27, 2022 | Wolves | 122 | Bucks | 116 |
| January | 29, 2022 | Spurs | 115 | Bucks | 117 |
| January | 30, 2022 | Suns | 118 | Bucks | 126 |
| February | 1, 2022 | Grizzlies | 127 | Bucks | 104 |
| February | 2, 2022 | Pacers | 103 | Bucks | 138 |
| February | 8, 2022 | Nets | 106 | Bucks | 107 |
| February | 11, 2022 | Bucks | 105 | Bulls | 91 |
| February | 16, 2022 | Bucks | 107 | Heat | 102 |
| February | 18, 2022 | Bucks | 115 | Grizzlies | 113 |
| February | 19, 2022 | Hawks | 126 | Bucks | 99 |
| February | 20, 2022 | Heat | 98 | Bucks | 127 |
| February | 21, 2022 | Bucks | 116 | Warriors | 138 |
| February | 24, 2022 | Bucks | 114 | Grizzlies | 124 |
| February | 25, 2022 | Bucks | 104 | Grizzlies | 122 |
| February | 26, 2022 | Bucks | 122 | Grizzlies | 116 |
| February | 28, 2022 | Bulls | 124 | Bucks | 117 |
| March | 3, 2022 | Rockets | 123 | Bucks | 117 |
| March | 6, 2022 | Warriors | 120 | Bucks | 108 |
| March | 7, 2022 | Jazz | 128 | Bucks | 133 |
| March | 9, 2022 | Bucks | 119 | Raptors | 139 |
| March | 11, 2022 | Kings | 91 | Bucks | 115 |
| March | 12, 2022 | Bucks | 116 | Celtics | 121 |
| March | 14, 2022 | Clippers | 144 | Bucks | 140 |
| March | 16, 2022 | Bucks | 126 | Lakers | 129 |
| March | 17, 2022 | Nuggets | 153 | Bucks | 115 |
| March | 23, 2022 | Pacers | 99 | Bucks | 127 |
| March | 24, 2022 | Bucks | 100 | Hawks | 121 |
| March | 25, 2022 | Bucks | 128 | Raptors | 116 |
| March | 29, 2022 | Bucks | 112 | Nuggets | 132 |
| March | 30, 2022 | Celtics | 139 | Bucks | 119 |
| April | 2, 2022 | Pacers | 126 | Bucks | 118 |
| April | 3, 2022 | Bucks | 111 | Rockets | 133 |
| April | 9, 2022 | Bucks | 113 | Jazz | 108 |
| April | 13, 2022 | Bucks | 126 | Clippers | 111 |
| April | 15, 2022 | Celtics | 121 | Bucks | 126 |
| April | 19, 2022 | Nets | 125 | Bucks | 122 |
| April | 21, 2022 | Bucks | 114 | Bulls | 127 |
| April | 22, 2022 | Pelicans | 102 | Bucks | 139 |
| April | 23, 2022 | Raptors | 118 | Bucks | 112 |
| April | 25, 2022 | Pelicans | 120 | Bucks | 138 |
| April | 26, 2022 | Bucks | 106 | Bulls | 129 |