| month | day | visitor | score | home | score |
|---|
| November | 3, 2020 | Warriors | 91 | Lakers | 130 |
| November | 4, 2020 | Warriors | 99 | Lakers | 127 |
| November | 5, 2020 | Clippers | 112 | Lakers | 117 |
| November | 6, 2020 | Lakers | 122 | Hawks | 101 |
| November | 7, 2020 | Lakers | 106 | Jazz | 109 |
| November | 8, 2020 | Bulls | 88 | Lakers | 128 |
| November | 10, 2020 | Lakers | 119 | Clippers | 104 |
| November | 12, 2020 | Lakers | 100 | Nuggets | 111 |
| November | 13, 2020 | Lakers | 126 | Spurs | 90 |
| November | 14, 2020 | Lakers | 127 | Wolves | 117 |
| November | 15, 2020 | Kings | 89 | Lakers | 125 |
| November | 20, 2020 | Lakers | 114 | Bucks | 102 |
| November | 22, 2020 | Suns | 97 | Lakers | 116 |
| November | 23, 2020 | Lakers | 89 | Heat | 95 |
| November | 25, 2020 | Sonics | 97 | Lakers | 111 |
| November | 26, 2020 | Lakers | 120 | Warriors | 105 |
| December | 1, 2020 | Pelicans | 98 | Lakers | 114 |
| December | 3, 2020 | Rockets | 71 | Lakers | 117 |
| December | 5, 2020 | Lakers | 118 | Kings | 107 |
| December | 7, 2020 | Clippers | 98 | Lakers | 113 |
| December | 8, 2020 | Kings | 100 | Lakers | 96 |
| December | 12, 2020 | Lakers | 140 | Raptors | 101 |
| December | 14, 2020 | Lakers | 102 | Clippers | 115 |
| December | 15, 2020 | Grizzlies | 114 | Lakers | 137 |
| December | 19, 2020 | Jazz | 99 | Lakers | 137 |
| December | 21, 2020 | Sonics | 86 | Lakers | 108 |
| December | 23, 2020 | Knicks | 95 | Lakers | 113 |
| December | 24, 2020 | Clippers | 109 | Lakers | 129 |
| December | 25, 2020 | Lakers | 91 | Clippers | 118 |
| December | 29, 2020 | Lakers | 120 | Blazers | 103 |
| December | 31, 2020 | Lakers | 109 | Celtics | 115 |
| January | 2, 2021 | Rockets | 108 | Lakers | 104 |
| January | 5, 2021 | Lakers | 126 | Spurs | 107 |
| January | 6, 2021 | Heat | 122 | Lakers | 117 |
| January | 7, 2021 | Kings | 115 | Lakers | 118 |
| January | 8, 2021 | Lakers | 108 | Nets | 106 |
| January | 14, 2021 | Lakers | 108 | Mavericks | 93 |
| January | 15, 2021 | Lakers | 136 | Blazers | 122 |
| January | 16, 2021 | Raptors | 110 | Lakers | 115 |
| January | 18, 2021 | Lakers | 115 | Rockets | 126 |
| January | 20, 2021 | Lakers | 108 | Nuggets | 119 |
| January | 21, 2021 | Lakers | 103 | Kings | 94 |
| January | 23, 2021 | Lakers | 125 | Jazz | 98 |
| January | 31, 2021 | Lakers | 104 | Knicks | 108 |
| February | 1, 2021 | Sonics | 119 | Lakers | 121 |
| February | 8, 2021 | Nuggets | 86 | Lakers | 112 |
| February | 9, 2021 | 76ers | 95 | Lakers | 125 |
| February | 14, 2021 | Blazers | 113 | Lakers | 121 |
| February | 15, 2021 | Lakers | 119 | Warriors | 129 |
| February | 18, 2021 | Jazz | 100 | Lakers | 109 |
| February | 20, 2021 | Lakers | 104 | Rockets | 120 |
| February | 21, 2021 | Nets | 108 | Lakers | 114 |
| February | 22, 2021 | Lakers | 95 | Suns | 92 |
| February | 25, 2021 | Celtics | 109 | Lakers | 119 |
| February | 28, 2021 | Lakers | 105 | Pelicans | 124 |
| March | 1, 2021 | Lakers | 135 | 76ers | 86 |
| March | 2, 2021 | Wolves | 102 | Lakers | 119 |
| March | 3, 2021 | Lakers | 112 | Grizzlies | 88 |
| March | 6, 2021 | Mavericks | 93 | Lakers | 109 |
| March | 9, 2021 | Spurs | 87 | Lakers | 116 |
| March | 10, 2021 | Warriors | 109 | Lakers | 133 |
| March | 12, 2021 | Spurs | 99 | Lakers | 114 |
| March | 16, 2021 | Bucks | 111 | Lakers | 128 |
| March | 18, 2021 | Suns | 97 | Lakers | 100 |
| March | 19, 2021 | Nuggets | 113 | Lakers | 121 |
| March | 23, 2021 | Lakers | 133 | Sonics | 105 |
| March | 26, 2021 | Lakers | 106 | Kings | 86 |
| March | 27, 2021 | Wolves | 113 | Lakers | 126 |
| March | 28, 2021 | Lakers | 141 | Blazers | 122 |
| March | 31, 2021 | Pacers | 92 | Lakers | 133 |
| April | 2, 2021 | Lakers | 105 | Mavericks | 108 |
| April | 8, 2021 | Lakers | 101 | Bulls | 104 |
| April | 10, 2021 | Lakers | 105 | Pacers | 99 |
| April | 11, 2021 | Lakers | 117 | Warriors | 115 |
| April | 15, 2021 | Blazers | 107 | Lakers | 138 |
| April | 16, 2021 | Lakers | 114 | Sonics | 101 |
| April | 17, 2021 | Hawks | 90 | Lakers | 118 |
| April | 18, 2021 | Lakers | 124 | Suns | 100 |
| April | 21, 2021 | Lakers | 108 | Wolves | 113 |
| April | 22, 2021 | Lakers | 111 | Sonics | 98 |
| April | 23, 2021 | Mavericks | 95 | Lakers | 122 |
| April | 25, 2021 | Blazers | 126 | Lakers | 142 |
| Post | 1, 2021 | Jazz | 96 | Lakers | 122 |
| Post | 2, 2021 | Jazz | 85 | Lakers | 111 |
| Post | 3, 2021 | Lakers | 112 | Jazz | 104 |
| Post | 4, 2021 | Lakers | 110 | Jazz | 121 |
| Post | 5, 2021 | Jazz | 119 | Lakers | 128 |
| Post | 6, 2021 | Lakers | | Jazz | |
| Post | 7, 2021 | Jazz | | Lakers | |
| Post | 8, 2021 | Wolves | 115 | Lakers | 123 |
| Post | 9, 2021 | Wolves | 101 | Lakers | 129 |
| Post | 10, 2021 | Lakers | 110 | Wolves | 101 |
| Post | 11, 2021 | Lakers | 132 | Wolves | 123 |
| Post | 12, 2021 | Wolves | | Lakers | |
| Post | 13, 2021 | Lakers | | Wolves | |
| Post | 14, 2021 | Wolves | | Lakers | |
| Post | 15, 2021 | Lakers | 88 | Rockets | 113 |
| Post | 16, 2021 | Lakers | 101 | Rockets | 107 |
| Post | 17, 2021 | Rockets | 102 | Lakers | 97 |
| Post | 18, 2021 | Rockets | 123 | Lakers | 103 |
| Post | 19, 2021 | Lakers | | Rockets | |
| Post | 20, 2021 | Rockets | | Lakers | |
| Post | 21, 2021 | Lakers | | Rockets | |