| month | day | visitor | score | home | score |
|---|
| November | 2, 2020 | Nets | 107 | Bulls | 98 |
| November | 8, 2020 | Bulls | 88 | Lakers | 128 |
| November | 9, 2020 | Bulls | 79 | 76ers | 98 |
| November | 10, 2020 | Warriors | 115 | Bulls | 93 |
| November | 14, 2020 | 76ers | 98 | Bulls | 95 |
| November | 15, 2020 | Bulls | 90 | Knicks | 111 |
| November | 16, 2020 | Bulls | 90 | Bucks | 111 |
| November | 17, 2020 | Bulls | 87 | Hawks | 116 |
| November | 19, 2020 | Bulls | 106 | Wolves | 118 |
| November | 20, 2020 | Raptors | 123 | Bulls | 92 |
| November | 21, 2020 | Bulls | 83 | Grizzlies | 109 |
| November | 25, 2020 | Bulls | 102 | Celtics | 97 |
| November | 26, 2020 | Bucks | 117 | Bulls | 107 |
| December | 3, 2020 | Bulls | 122 | Suns | 116 |
| December | 6, 2020 | Bulls | 110 | Hawks | 108 |
| December | 7, 2020 | Bulls | 97 | Pelicans | 128 |
| December | 8, 2020 | Bulls | 95 | Hawks | 115 |
| December | 9, 2020 | Bulls | 129 | Raptors | 138 |
| December | 11, 2020 | Bulls | 100 | Grizzlies | 105 |
| December | 13, 2020 | Bulls | 99 | Kings | 129 |
| December | 14, 2020 | Pelicans | 128 | Bulls | 98 |
| December | 17, 2020 | Celtics | 123 | Bulls | 97 |
| December | 19, 2020 | Knicks | 104 | Bulls | 105 |
| December | 20, 2020 | Suns | 106 | Bulls | 123 |
| December | 21, 2020 | Bulls | 88 | Heat | 83 |
| December | 22, 2020 | Bulls | 108 | Clippers | 111 |
| December | 24, 2020 | Bulls | 95 | Pacers | 113 |
| December | 26, 2020 | Sonics | 111 | Bulls | 115 |
| December | 30, 2020 | Bulls | 108 | Rockets | 123 |
| December | 31, 2020 | Clippers | 111 | Bulls | 116 |
| January | 3, 2021 | Hawks | 107 | Bulls | 121 |
| January | 5, 2021 | Bulls | 88 | Mavericks | 104 |
| January | 7, 2021 | Bulls | 120 | Warriors | 98 |
| January | 9, 2021 | Heat | 90 | Bulls | 110 |
| January | 11, 2021 | Kings | 124 | Bulls | 123 |
| January | 12, 2021 | Bulls | 102 | Jazz | 124 |
| January | 16, 2021 | Bulls | 108 | Hawks | 102 |
| January | 21, 2021 | Jazz | 97 | Bulls | 107 |
| January | 22, 2021 | Hawks | 115 | Bulls | 104 |
| January | 25, 2021 | Spurs | 99 | Bulls | 103 |
| January | 26, 2021 | Pelicans | 126 | Bulls | 117 |
| January | 28, 2021 | Bulls | 119 | Grizzlies | 110 |
| January | 29, 2021 | Wolves | 150 | Bulls | 133 |
| January | 30, 2021 | 76ers | 118 | Bulls | 114 |
| February | 1, 2021 | Pacers | 107 | Bulls | 109 |
| February | 9, 2021 | Bulls | 120 | Nuggets | 122 |
| February | 11, 2021 | Bucks | 140 | Bulls | 119 |
| February | 12, 2021 | Bulls | 94 | Raptors | 115 |
| February | 14, 2021 | Mavericks | 99 | Bulls | 103 |
| February | 16, 2021 | Bulls | 120 | Spurs | 112 |
| February | 18, 2021 | Bulls | 94 | Pacers | 114 |
| February | 19, 2021 | Bulls | 121 | Grizzlies | 98 |
| February | 20, 2021 | Grizzlies | 88 | Bulls | 126 |
| February | 22, 2021 | Bulls | 96 | Pacers | 124 |
| February | 28, 2021 | Bulls | 95 | Bucks | 125 |
| March | 1, 2021 | Bulls | 108 | Celtics | 137 |
| March | 4, 2021 | Raptors | 117 | Bulls | 124 |
| March | 7, 2021 | Bulls | 110 | Nets | 123 |
| March | 8, 2021 | Pelicans | 125 | Bulls | 101 |
| March | 9, 2021 | Celtics | 124 | Bulls | 89 |
| March | 10, 2021 | Bulls | 109 | Celtics | 117 |
| March | 16, 2021 | Grizzlies | 86 | Bulls | 122 |
| March | 20, 2021 | Heat | 79 | Bulls | 84 |
| March | 21, 2021 | Bulls | 111 | 76ers | 88 |
| March | 22, 2021 | Bulls | 109 | Blazers | 143 |
| March | 23, 2021 | Nets | 108 | Bulls | 103 |
| March | 24, 2021 | Blazers | 137 | Bulls | 131 |
| March | 27, 2021 | Rockets | 108 | Bulls | 102 |
| March | 28, 2021 | Pacers | 110 | Bulls | 97 |
| March | 31, 2021 | Nuggets | 94 | Bulls | 119 |
| April | 1, 2021 | Knicks | 119 | Bulls | 104 |
| April | 4, 2021 | Bulls | 92 | Heat | 105 |
| April | 5, 2021 | Bulls | 74 | Knicks | 112 |
| April | 6, 2021 | Nets | 112 | Bulls | 92 |
| April | 8, 2021 | Lakers | 101 | Bulls | 104 |
| April | 9, 2021 | Bulls | 95 | 76ers | 101 |
| April | 15, 2021 | Raptors | 121 | Bulls | 99 |
| April | 18, 2021 | Bulls | 98 | Sonics | 104 |
| April | 19, 2021 | Pacers | 117 | Bulls | 121 |
| April | 21, 2021 | Bucks | 130 | Bulls | 103 |
| April | 24, 2021 | Bulls | 105 | Raptors | 140 |
| April | 26, 2021 | Bucks | 116 | Bulls | 127 |