| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | Celtics | 128 | Knicks | 113 |
| November | 3, 2021 | Knicks | 90 | 76ers | 100 |
| November | 4, 2021 | Knicks | 121 | Spurs | 102 |
| November | 6, 2021 | Knicks | 104 | Nets | 121 |
| November | 7, 2021 | 76ers | 86 | Knicks | 119 |
| November | 13, 2021 | Knicks | 92 | Pelicans | 103 |
| November | 15, 2021 | Bulls | 130 | Knicks | 125 |
| November | 17, 2021 | Raptors | 132 | Knicks | 133 |
| November | 19, 2021 | Knicks | 131 | Bucks | 124 |
| November | 21, 2021 | Blazers | 100 | Knicks | 81 |
| November | 24, 2021 | Grizzlies | 112 | Knicks | 104 |
| November | 26, 2021 | Pelicans | 116 | Knicks | 127 |
| November | 27, 2021 | Heat | 105 | Knicks | 99 |
| November | 28, 2021 | Knicks | 113 | Heat | 104 |
| November | 29, 2021 | Knicks | 122 | Nets | 100 |
| November | 30, 2021 | Knicks | 92 | Blazers | 90 |
| December | 2, 2021 | Knicks | 112 | Clippers | 122 |
| December | 4, 2021 | Knicks | 115 | Nets | 110 |
| December | 6, 2021 | Sonics | 90 | Knicks | 121 |
| December | 7, 2021 | Nets | 93 | Knicks | 82 |
| December | 9, 2021 | Pacers | 102 | Knicks | 132 |
| December | 10, 2021 | Heat | 94 | Knicks | 89 |
| December | 11, 2021 | Knicks | 100 | Pacers | 108 |
| December | 12, 2021 | 76ers | 101 | Knicks | 100 |
| December | 14, 2021 | Knicks | 95 | Raptors | 105 |
| December | 15, 2021 | Knicks | 131 | Bucks | 105 |
| December | 18, 2021 | Nets | 101 | Knicks | 120 |
| December | 19, 2021 | Knicks | 120 | Bulls | 115 |
| December | 23, 2021 | Knicks | 138 | Lakers | 106 |
| December | 25, 2021 | Jazz | 95 | Knicks | 119 |
| December | 26, 2021 | Raptors | 115 | Knicks | 132 |
| December | 28, 2021 | Knicks | 127 | Celtics | 113 |
| December | 30, 2021 | 76ers | 90 | Knicks | 115 |
| January | 4, 2022 | Knicks | 113 | Raptors | 92 |
| January | 5, 2022 | Knicks | 109 | Bucks | 126 |
| January | 8, 2022 | Knicks | 115 | Celtics | 120 |
| January | 9, 2022 | Knicks | 104 | Hawks | 130 |
| January | 10, 2022 | Knicks | 127 | Suns | 104 |
| January | 11, 2022 | Hawks | 121 | Knicks | 110 |
| January | 13, 2022 | Bucks | 124 | Knicks | 123 |
| January | 17, 2022 | Knicks | 109 | Pacers | 98 |
| January | 18, 2022 | Knicks | 112 | Nuggets | 121 |
| January | 24, 2022 | Grizzlies | 112 | Knicks | 106 |
| January | 26, 2022 | Heat | 91 | Knicks | 112 |
| January | 28, 2022 | Hawks | 120 | Knicks | 132 |
| January | 29, 2022 | Knicks | 108 | 76ers | 94 |
| January | 30, 2022 | Grizzlies | 113 | Knicks | 111 |
| January | 31, 2022 | Lakers | 92 | Knicks | 124 |
| February | 4, 2022 | Pacers | 116 | Knicks | 122 |
| February | 14, 2022 | Rockets | 128 | Knicks | 123 |
| February | 17, 2022 | Nuggets | 101 | Knicks | 104 |
| February | 18, 2022 | Wolves | 112 | Knicks | 136 |
| February | 19, 2022 | Knicks | 122 | 76ers | 100 |
| February | 22, 2022 | Knicks | 117 | Warriors | 119 |
| February | 25, 2022 | Knicks | 112 | Pelicans | 131 |
| February | 27, 2022 | Knicks | 94 | Kings | 88 |
| March | 2, 2022 | Spurs | 98 | Knicks | 130 |
| March | 4, 2022 | Celtics | 145 | Knicks | 130 |
| March | 5, 2022 | Warriors | 87 | Knicks | 119 |
| March | 7, 2022 | Clippers | 144 | Knicks | 140 |
| March | 8, 2022 | Knicks | 129 | Mavericks | 100 |
| March | 9, 2022 | Hawks | 128 | Knicks | 114 |
| March | 11, 2022 | Knicks | 107 | Nets | 137 |
| March | 17, 2022 | Celtics | 104 | Knicks | 118 |
| March | 18, 2022 | Celtics | 128 | Knicks | 130 |
| March | 19, 2022 | Knicks | 122 | Pelicans | 104 |
| March | 22, 2022 | Knicks | 134 | Hawks | 107 |
| March | 25, 2022 | Knicks | 136 | Rockets | 131 |
| March | 31, 2022 | Pelicans | 105 | Knicks | 133 |
| April | 1, 2022 | Knicks | 96 | Bulls | 117 |
| April | 3, 2022 | Mavericks | 113 | Knicks | 121 |
| April | 5, 2022 | Bulls | 112 | Knicks | 118 |
| April | 6, 2022 | Kings | 89 | Knicks | 93 |
| April | 7, 2022 | Heat | 87 | Knicks | 92 |
| April | 11, 2022 | Knicks | 124 | Pelicans | 113 |
| April | 14, 2022 | Suns | 107 | Knicks | 118 |
| April | 17, 2022 | Knicks | 108 | Wolves | 116 |
| April | 20, 2022 | Knicks | 112 | Sonics | 101 |
| April | 21, 2022 | Knicks | 133 | Jazz | 119 |
| April | 22, 2022 | Knicks | 110 | Heat | 103 |
| April | 23, 2022 | Knicks | 116 | Grizzlies | 86 |
| April | 26, 2022 | Knicks | 118 | Grizzlies | 125 |
| Post | 1, 2022 | Raptors | 105 | Knicks | 103 |
| Post | 2, 2022 | Raptors | 122 | Knicks | 124 |
| Post | 3, 2022 | Knicks | 134 | Raptors | 111 |
| Post | 4, 2022 | Knicks | 123 | Raptors | 105 |
| Post | 5, 2022 | Raptors | 102 | Knicks | 94 |
| Post | 6, 2022 | Knicks | 127 | Raptors | 115 |
| Post | 7, 2022 | Raptors | | Knicks | |
| Post | 8, 2022 | Pelicans | 119 | Knicks | 115 |
| Post | 9, 2022 | Pelicans | 116 | Knicks | 129 |
| Post | 10, 2022 | Knicks | 123 | Pelicans | 128 |
| Post | 11, 2022 | Knicks | 111 | Pelicans | 124 |
| Post | 12, 2022 | Pelicans | 126 | Knicks | 117 |
| Post | 13, 2022 | Knicks | | Pelicans | |
| Post | 14, 2022 | Pelicans | | Knicks | |