| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | Warriors | 103 | Clippers | 115 |
| November | 4, 2021 | Pacers | 131 | Clippers | 122 |
| November | 5, 2021 | Clippers | 126 | Lakers | 121 |
| November | 7, 2021 | Suns | 102 | Clippers | 114 |
| November | 8, 2021 | Wolves | 108 | Clippers | 137 |
| November | 10, 2021 | Lakers | 113 | Clippers | 120 |
| November | 11, 2021 | Jazz | 123 | Clippers | 126 |
| November | 15, 2021 | Warriors | 99 | Clippers | 135 |
| November | 17, 2021 | Sonics | 112 | Clippers | 110 |
| November | 21, 2021 | Nuggets | 123 | Clippers | 112 |
| November | 25, 2021 | Clippers | 81 | Pelicans | 133 |
| November | 30, 2021 | Clippers | 110 | Kings | 115 |
| December | 1, 2021 | Clippers | 124 | Pacers | 115 |
| December | 2, 2021 | Knicks | 112 | Clippers | 122 |
| December | 6, 2021 | Spurs | 118 | Clippers | 108 |
| December | 7, 2021 | Clippers | 132 | Lakers | 111 |
| December | 11, 2021 | Pelicans | 122 | Clippers | 120 |
| December | 12, 2021 | Clippers | 114 | Rockets | 123 |
| December | 14, 2021 | Lakers | 110 | Clippers | 112 |
| December | 15, 2021 | Clippers | 115 | Wolves | 118 |
| December | 18, 2021 | Clippers | 112 | Mavericks | 118 |
| December | 19, 2021 | Mavericks | 131 | Clippers | 103 |
| December | 20, 2021 | Nets | 105 | Clippers | 102 |
| December | 22, 2021 | Bulls | 122 | Clippers | 98 |
| December | 24, 2021 | Clippers | 106 | Lakers | 110 |
| December | 25, 2021 | Lakers | 108 | Clippers | 111 |
| December | 28, 2021 | Clippers | 124 | Raptors | 128 |
| December | 30, 2021 | Mavericks | 122 | Clippers | 124 |
| December | 31, 2021 | Clippers | 125 | Bulls | 120 |
| January | 1, 2022 | Clippers | 104 | Rockets | 130 |
| January | 5, 2022 | Kings | 78 | Clippers | 120 |
| January | 9, 2022 | Spurs | 103 | Clippers | 117 |
| January | 10, 2022 | Clippers | 108 | Blazers | 118 |
| January | 11, 2022 | Clippers | 140 | Spurs | 99 |
| January | 14, 2022 | Clippers | 126 | Warriors | 116 |
| January | 18, 2022 | Clippers | 127 | Warriors | 119 |
| January | 19, 2022 | Heat | 116 | Clippers | 118 |
| January | 21, 2022 | Clippers | 131 | Spurs | 113 |
| January | 24, 2022 | Clippers | 109 | Nets | 145 |
| January | 25, 2022 | Clippers | 140 | Warriors | 107 |
| January | 29, 2022 | Raptors | 120 | Clippers | 139 |
| February | 1, 2022 | Clippers | 134 | Hawks | 142 |
| February | 4, 2022 | Clippers | 119 | Grizzlies | 127 |
| February | 9, 2022 | Suns | 120 | Clippers | 121 |
| February | 10, 2022 | Clippers | 106 | Heat | 121 |
| February | 11, 2022 | Hawks | 111 | Clippers | 129 |
| February | 12, 2022 | 76ers | 97 | Clippers | 121 |
| February | 15, 2022 | Clippers | 117 | Kings | 108 |
| February | 16, 2022 | Clippers | 104 | Kings | 106 |
| February | 21, 2022 | Sonics | 115 | Clippers | 134 |
| February | 23, 2022 | Clippers | 116 | 76ers | 100 |
| February | 25, 2022 | Clippers | 107 | Suns | 98 |
| February | 26, 2022 | Clippers | 123 | Celtics | 125 |
| February | 27, 2022 | Clippers | 121 | Nuggets | 125 |
| March | 1, 2022 | Clippers | 123 | Mavericks | 120 |
| March | 2, 2022 | Sonics | 112 | Clippers | 139 |
| March | 3, 2022 | Kings | 100 | Clippers | 122 |
| March | 7, 2022 | Clippers | 144 | Knicks | 140 |
| March | 11, 2022 | Clippers | 116 | Nuggets | 131 |
| March | 13, 2022 | Kings | 114 | Clippers | 122 |
| March | 14, 2022 | Clippers | 144 | Bucks | 140 |
| March | 15, 2022 | Clippers | 137 | Blazers | 111 |
| March | 18, 2022 | Clippers | 129 | Jazz | 132 |
| March | 21, 2022 | Warriors | 112 | Clippers | 135 |
| March | 22, 2022 | Clippers | 131 | Sonics | 103 |
| March | 23, 2022 | Grizzlies | 119 | Clippers | 116 |
| March | 30, 2022 | Rockets | 122 | Clippers | 156 |
| March | 31, 2022 | Clippers | 119 | Blazers | 123 |
| April | 1, 2022 | Nuggets | 121 | Clippers | 124 |
| April | 2, 2022 | Clippers | 122 | Sonics | 123 |
| April | 7, 2022 | Celtics | 119 | Clippers | 131 |
| April | 9, 2022 | Blazers | 101 | Clippers | 115 |
| April | 11, 2022 | Clippers | 139 | Jazz | 133 |
| April | 12, 2022 | Wolves | 121 | Clippers | 144 |
| April | 13, 2022 | Bucks | 126 | Clippers | 111 |
| April | 16, 2022 | Clippers | 116 | Wolves | 117 |
| April | 17, 2022 | Rockets | 129 | Clippers | 127 |
| April | 19, 2022 | Blazers | 109 | Clippers | 119 |
| April | 20, 2022 | Jazz | 129 | Clippers | 147 |
| April | 21, 2022 | Clippers | 136 | Suns | 103 |
| April | 24, 2022 | Blazers | 100 | Clippers | 114 |
| April | 25, 2022 | Clippers | 119 | Sonics | 108 |
| Post | 1, 2022 | Kings | 80 | Clippers | 103 |
| Post | 2, 2022 | Kings | 110 | Clippers | 114 |
| Post | 3, 2022 | Clippers | 130 | Kings | 106 |
| Post | 4, 2022 | Clippers | 127 | Kings | 103 |
| Post | 5, 2022 | Kings | | Clippers | |
| Post | 6, 2022 | Clippers | | Kings | |
| Post | 7, 2022 | Kings | | Clippers | |
| Post | 8, 2022 | Clippers | 120 | Wolves | 117 |
| Post | 9, 2022 | Clippers | 105 | Wolves | 125 |
| Post | 10, 2022 | Wolves | 103 | Clippers | 128 |
| Post | 11, 2022 | Wolves | 134 | Clippers | 136 |
| Post | 12, 2022 | Clippers | 117 | Wolves | 142 |
| Post | 13, 2022 | Wolves | 90 | Clippers | 131 |
| Post | 14, 2022 | Clippers | | Wolves | |
| Post | 15, 2022 | Clippers | 131 | Rockets | 146 |
| Post | 16, 2022 | Clippers | 115 | Rockets | 136 |
| Post | 17, 2022 | Rockets | 145 | Clippers | 152 |
| Post | 18, 2022 | Rockets | 113 | Clippers | 129 |
| Post | 19, 2022 | Clippers | 114 | Rockets | 138 |
| Post | 20, 2022 | Rockets | 120 | Clippers | 135 |
| Post | 21, 2022 | Clippers | 111 | Rockets | 114 |