| month | day | visitor | score | home | score |
|---|
| November | 3, 2021 | Blazers | 115 | Jazz | 86 |
| November | 4, 2021 | Nets | 76 | Blazers | 93 |
| November | 6, 2021 | Blazers | 97 | 76ers | 82 |
| November | 12, 2021 | Mavericks | 100 | Blazers | 102 |
| November | 13, 2021 | Blazers | 101 | Warriors | 98 |
| November | 16, 2021 | Kings | 85 | Blazers | 81 |
| November | 17, 2021 | Pacers | 89 | Blazers | 137 |
| November | 20, 2021 | Blazers | 94 | Pelicans | 108 |
| November | 21, 2021 | Blazers | 100 | Knicks | 81 |
| November | 24, 2021 | Blazers | 97 | Jazz | 87 |
| November | 26, 2021 | Rockets | 110 | Blazers | 96 |
| November | 30, 2021 | Knicks | 92 | Blazers | 90 |
| December | 1, 2021 | Blazers | 102 | Kings | 89 |
| December | 2, 2021 | Blazers | 93 | Nets | 107 |
| December | 3, 2021 | Jazz | 78 | Blazers | 90 |
| December | 4, 2021 | Bucks | 117 | Blazers | 123 |
| December | 7, 2021 | Blazers | 99 | Sonics | 94 |
| December | 10, 2021 | Raptors | 118 | Blazers | 117 |
| December | 11, 2021 | Sonics | 76 | Blazers | 100 |
| December | 14, 2021 | Blazers | 100 | Sonics | 116 |
| December | 16, 2021 | Nuggets | 107 | Blazers | 86 |
| December | 18, 2021 | Heat | 83 | Blazers | 113 |
| December | 20, 2021 | Blazers | 102 | Wolves | 94 |
| December | 22, 2021 | Jazz | 90 | Blazers | 109 |
| December | 24, 2021 | Blazers | 94 | Heat | 110 |
| December | 25, 2021 | Blazers | 115 | Sonics | 107 |
| December | 26, 2021 | Pelicans | 104 | Blazers | 100 |
| December | 27, 2021 | Blazers | 101 | Mavericks | 114 |
| December | 28, 2021 | Blazers | 85 | Mavericks | 104 |
| December | 29, 2021 | Lakers | 76 | Blazers | 121 |
| January | 1, 2022 | Blazers | 104 | Spurs | 90 |
| January | 2, 2022 | Sonics | 114 | Blazers | 107 |
| January | 4, 2022 | Warriors | 105 | Blazers | 99 |
| January | 6, 2022 | Kings | 105 | Blazers | 100 |
| January | 10, 2022 | Clippers | 108 | Blazers | 118 |
| January | 11, 2022 | Blazers | 112 | Bucks | 122 |
| January | 12, 2022 | Kings | 92 | Blazers | 88 |
| January | 15, 2022 | Lakers | 74 | Blazers | 105 |
| January | 16, 2022 | Blazers | 109 | Warriors | 81 |
| January | 17, 2022 | Suns | 106 | Blazers | 108 |
| January | 19, 2022 | Wolves | 101 | Blazers | 99 |
| January | 21, 2022 | Wolves | 106 | Blazers | 101 |
| January | 23, 2022 | Warriors | 96 | Blazers | 101 |
| January | 26, 2022 | Blazers | 103 | Pacers | 115 |
| January | 27, 2022 | Nuggets | 92 | Blazers | 88 |
| January | 28, 2022 | Blazers | 98 | Spurs | 106 |
| February | 4, 2022 | Blazers | 116 | Nuggets | 98 |
| February | 8, 2022 | Blazers | 97 | Rockets | 112 |
| February | 10, 2022 | 76ers | 88 | Blazers | 98 |
| February | 11, 2022 | Sonics | 90 | Blazers | 91 |
| February | 14, 2022 | Blazers | 83 | Lakers | 99 |
| February | 17, 2022 | Blazers | 97 | Suns | 113 |
| February | 20, 2022 | Blazers | 92 | Kings | 78 |
| February | 23, 2022 | Celtics | 105 | Blazers | 117 |
| March | 1, 2022 | Blazers | 99 | Nuggets | 84 |
| March | 6, 2022 | Blazers | 97 | Kings | 71 |
| March | 9, 2022 | Rockets | 101 | Blazers | 97 |
| March | 12, 2022 | Blazers | 97 | Rockets | 101 |
| March | 13, 2022 | Blazers | 122 | Raptors | 129 |
| March | 15, 2022 | Clippers | 137 | Blazers | 111 |
| March | 19, 2022 | Blazers | 98 | Warriors | 103 |
| March | 21, 2022 | Hawks | 115 | Blazers | 137 |
| March | 22, 2022 | Bulls | 89 | Blazers | 118 |
| March | 24, 2022 | Blazers | 95 | Bulls | 91 |
| March | 28, 2022 | Lakers | 90 | Blazers | 116 |
| March | 31, 2022 | Clippers | 119 | Blazers | 123 |
| April | 1, 2022 | Blazers | 117 | Wolves | 119 |
| April | 3, 2022 | Blazers | 93 | Suns | 110 |
| April | 5, 2022 | Suns | 104 | Blazers | 88 |
| April | 6, 2022 | Grizzlies | 91 | Blazers | 90 |
| April | 9, 2022 | Blazers | 101 | Clippers | 115 |
| April | 10, 2022 | Mavericks | 78 | Blazers | 103 |
| April | 11, 2022 | Spurs | 105 | Blazers | 113 |
| April | 13, 2022 | Blazers | 92 | Grizzlies | 113 |
| April | 14, 2022 | Blazers | 116 | Celtics | 115 |
| April | 15, 2022 | Blazers | 95 | Lakers | 107 |
| April | 19, 2022 | Blazers | 109 | Clippers | 119 |
| April | 21, 2022 | Warriors | 105 | Blazers | 104 |
| April | 22, 2022 | Spurs | 93 | Blazers | 97 |
| April | 23, 2022 | Blazers | 116 | Hawks | 93 |
| April | 24, 2022 | Blazers | 100 | Clippers | 114 |
| April | 25, 2022 | Blazers | 104 | Lakers | 106 |
| Post | 1, 2022 | Blazers | 92 | Wolves | 106 |
| Post | 2, 2022 | Blazers | 104 | Wolves | 78 |
| Post | 3, 2022 | Wolves | 88 | Blazers | 93 |
| Post | 4, 2022 | Wolves | 90 | Blazers | 114 |
| Post | 5, 2022 | Blazers | 93 | Wolves | 100 |
| Post | 6, 2022 | Wolves | 91 | Blazers | 85 |
| Post | 7, 2022 | Blazers | 80 | Wolves | 97 |